%0 Journal Article
%T 肿瘤源性外泌体与白血病关系的研究进展
%A 田翔宇
%A 陈奎生
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1961
%X 摘要 外泌体（exosomes）是一类直径介于30~150 nm之间的双层结构的微小囊泡，可由多种类型细胞分泌，内含丰富的蛋白质、mRNA和microRNA，参与细胞间物质交换和信号转导。外泌体通过影响细胞增殖、凋亡和自噬、调节骨髓微环境、促进血管生成以及抑制骨髓造血等多方面促进白血病的发生发展，影响白血病的耐药；同时可作为白血病药物治疗的作用靶点等。本文就外泌体的组成、形成和近年来肿瘤来源的外泌体在白血病中的作用研究进行综述
%K Three Cases Report and Literature Review
%K High-doses Granulocyte Colony-stimulating Factor (G-CSF) Benefit Elderly Patients with Acute Myeloid Leukemia
%K Expression of miR-155/PTEN Axis in Hepatocellular Carcinoma and Its Mechanism
%K Leukemia with Solid Tumor: A Case Report and Literature Review
%K Myelogenous Blast Crisis of Chronic Myeloid Leukemia(CML-BC) with Complex Karyotype and T Lymphocyte Lymphoma/Leukemia: A Case Report and Literature Review
%K Mixed-phenotype Acute Leukemia Developed by Chronic Myelogenous Leukemia: A Case Report and Literature Review
%K Trends of Leukemia Mortality in Kunshan City
%K Jiangsu Province from 1993 to 2014
%K Relationship of Expression Difference of miR-658 and miR-492 with Pelvic Lymph Node Metastasis from Squamous Carcinoma of Cervix
%K Effect of ΔNp63α on Leukemia Inhibitory Factor Expression in Cervical Cancer Cells and Related Mechanism
%K Research Progress of Relationship Between Urokinase Plasminogen Activator System and Acute Myelocytic Leukemia
%K Reversion Impact of Peptide Extract from Scorpion Venom on Multidrug-resistance of Leukemia Stem Cell Line K562/A02 in vivo
%K NOTCH1 Down-regulates Tumor Suppressor Gene ID4 in T-cell Acute Lymphoblastic Leukemia
%K Targeted Therapy with Sorafenib for FLT3-ITD-positive Acute Myeloid Leukemia Patients
%U http://www.zlfzyj.com/CN/abstract/abstract9438.shtml