PKM2表达和巨噬细胞中CD163升高协同促进骨肉瘤进展
DOI: 10.3971/j.issn.1000-8578.2019.19.0453
Keywords: A Case Report and Literature Review,Research Progress in Effect of miR-17-92 Cluster in Osteosarcoma,Downregulation of Skp2 Expression Inhibits Malignant Phenotype of Osteosarcoma U2OS Cells,Correlation of Hypothyroidism and Endometrial Carcinoma,Breast Metastasis of Primary Pulmonary Adenocarcinoma: A Report of Two Cases and Literature Review,HER2 (++) Amplification in Breast Cancer Detected by Fluorescence in Situ Hybridization and Its Correlation with Clinicopathological Features,Advances in Immunohistochemical Markers in Molecular Classification of Medulloblastoma,Renal Mesenchymal Chondrosarcoma: A Case Report and Literature Review,Micronodular Thymoma with Lymphoid Stroma: A Case Report,Construction of Gene-coregulation-network for Osteosarcoma MicroRNA,Napsin A, TTF1 and SPA Protein Expressions and Their Correlation with EGFR Gene Mutations in Primary Lung Adenocarcinoma,Expression of Ubiquilin1 Protein in Breast Cancer Tissues and Its Prognostic Significance,Expressions of PLAC8 Protein in Nasopharyngeal Carcinoma Cells and Related Clinical Significance,Expression of Podocalyxin in Breast Cancer Tissues
Abstract:
摘要 目的 探讨骨肉瘤中PKM2与相关病理学特征的关系，以进一步寻找判断骨肉瘤预后的标志物。方法 收集原发性骨肉瘤石蜡包埋标本88例，并对标本进行组织微阵列构建，免疫组织化学法检测PKM2的表达情况， Kaplan-Meier分析预后价值，Cox回归模型进行参数与患者预后的相关性分析。结果 M2巨噬细胞特异性标志物CD163在骨肉瘤基质中升高，PKM2过表达与M2巨噬细胞浸润在骨肉瘤中呈正相关。结论 PKM2过表达和M2巨噬细胞浸润是骨肉瘤患者预后不良的因素
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