%0 Journal Article
%T PKM2表达和巨噬细胞中CD163升高协同促进骨肉瘤进展
%A 向仁堃
%A 夏雪
%A 杨俊涛
%A 王晓旭
%A 谭文甫
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.19.0453
%X 摘要 目的 探讨骨肉瘤中PKM2与相关病理学特征的关系，以进一步寻找判断骨肉瘤预后的标志物。方法 收集原发性骨肉瘤石蜡包埋标本88例，并对标本进行组织微阵列构建，免疫组织化学法检测PKM2的表达情况， Kaplan-Meier分析预后价值，Cox回归模型进行参数与患者预后的相关性分析。结果 M2巨噬细胞特异性标志物CD163在骨肉瘤基质中升高，PKM2过表达与M2巨噬细胞浸润在骨肉瘤中呈正相关。结论 PKM2过表达和M2巨噬细胞浸润是骨肉瘤患者预后不良的因素
%K A Case Report and Literature Review
%K Research Progress in Effect of miR-17-92 Cluster in Osteosarcoma
%K Downregulation of Skp2 Expression Inhibits Malignant Phenotype of Osteosarcoma U2OS Cells
%K Correlation of Hypothyroidism and Endometrial Carcinoma
%K Breast Metastasis of Primary Pulmonary Adenocarcinoma: A Report of Two Cases and Literature Review
%K HER2 (++) Amplification in Breast Cancer Detected by Fluorescence in Situ Hybridization and Its Correlation with Clinicopathological Features
%K Advances in Immunohistochemical Markers in Molecular Classification of Medulloblastoma
%K Renal Mesenchymal Chondrosarcoma: A Case Report and Literature Review
%K Micronodular Thymoma with Lymphoid Stroma: A Case Report
%K Construction of Gene-coregulation-network for Osteosarcoma MicroRNA
%K Napsin A
%K TTF1 and SPA Protein Expressions and Their Correlation with EGFR Gene Mutations in Primary Lung Adenocarcinoma
%K Expression of Ubiquilin1 Protein in Breast Cancer Tissues and Its Prognostic Significance
%K Expressions of PLAC8 Protein in Nasopharyngeal Carcinoma Cells and Related Clinical Significance
%K Expression of Podocalyxin in Breast Cancer Tissues
%U http://www.zlfzyj.com/CN/abstract/abstract9529.shtml