非小细胞肺癌患者外周血中WNT7A甲基化检测的诊断价值
DOI: 10.3971/j.issn.1000-8578.2019.19.0484
Keywords: WNT7A,甲基化,甲基化特异性聚合酶链反应,病理类型,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Comparison of Clinicopathological Characteristics of 3241 Lung Cancer Patients in He’nan in 2004 and 2014,Expression and DNA Methylation Status of Long Non-coding RNA ZNF667-AS1 in Esophageal Squamous Cell Carcinoma Tissues,Application of MGMT Promoter Methylation of Cerebrospinal Fluid in Diagnosis of Glioma,Correlation Between Codeletion of Chromosome 1p/19q and MGMT Promoter Methylation in Oligodendrogliomas,Research Progress of Lung Cancer in Young Patients,Clinical Significance of JAG1 Gene Methylation in Uygur Breast Cancer Patients,Research Progress on SPARC in Pathogenesis of Gastric Cancer,Expressions of SFRP1 Gene Methylation and SFRP1 Protein in Lung Adenocarcinoma and Related Clinical Significance,Methylation Status of MGMT Gene Promoter in Patients with Adenocarcinoma of Esophagogastric Junction and Its Relationship with Prognosis,Correlation of ChREBP mRNA Expression and Its CpG Island Methylation in Human Hepatocellular Carcinoma,Relationship of Methylation Status and mRNA Expression of PTEN, RASSF1A in Peripheral Blood with Thyroid Nodule Disease,Recent Advances of Correlation of Mismatch Repair System hMutS, hMutL Variation and Colorectal Cancer,Significance of Tumor Suppressor Gene TCF21 Promoter Methylation for Diagnosis and Prognosis of Renal Cell Carcinoma,Effect of Ubiquitin-like with PHD and Ring Finger Domain 1 on Invasion and Metastasis of Gastric Cancer and Related Mechanism
Abstract:
摘要 目的 探索WNT7A甲基化和NSCLC临床病理因素的关系。方法 选取120例NSCLC患者为NSCLC组，另外选择120位健康者为对照组，采用甲基化特异性聚合酶链反应（MSP）法检测两组的WNT7A启动子甲基化率，并分析WNT7A甲基化和NSCLC临床病理因素的关系。结果 NSCLC组患者的外周血中WNT7A甲基化率显著高于对照组（P<0.05），WNT7A基因甲基化率与患者的性别、病理类型、年龄、吸烟史等无显著相关性（P>0.05），而与肿瘤大小、远处转移、TNM分期、胸腔积液显著相关（P<0.05）。有胸腔积液、肿瘤直径＞5 cm的NSCLC患者外周血中WNT7A基因甲基化检出率显著高于无胸腔积液、肿瘤直径≤5 cm患者（均P<0.05）；TNM分期为Ⅲ~Ⅳ的NSCLC患者外周血中WNT7A基因甲基化检出率显著高于分期为Ⅰ~Ⅱ的NSCLC患者（P<0.05）。结论 WNT7A基因甲基化在NSCLC患者中检出率较高，可作为NSCLC有效的诊断依据
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