%0 Journal Article
%T 非小细胞肺癌患者外周血中WNT7A甲基化检测的诊断价值
%A 张军霞
%A 张畅
%A 彭黎
%A 徐瑶
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.19.0484
%X 摘要 目的 探索WNT7A甲基化和NSCLC临床病理因素的关系。方法 选取120例NSCLC患者为NSCLC组，另外选择120位健康者为对照组，采用甲基化特异性聚合酶链反应（MSP）法检测两组的WNT7A启动子甲基化率，并分析WNT7A甲基化和NSCLC临床病理因素的关系。结果 NSCLC组患者的外周血中WNT7A甲基化率显著高于对照组（P<0.05），WNT7A基因甲基化率与患者的性别、病理类型、年龄、吸烟史等无显著相关性（P>0.05），而与肿瘤大小、远处转移、TNM分期、胸腔积液显著相关（P<0.05）。有胸腔积液、肿瘤直径＞5 cm的NSCLC患者外周血中WNT7A基因甲基化检出率显著高于无胸腔积液、肿瘤直径≤5 cm患者（均P<0.05）；TNM分期为Ⅲ~Ⅳ的NSCLC患者外周血中WNT7A基因甲基化检出率显著高于分期为Ⅰ~Ⅱ的NSCLC患者（P<0.05）。结论 WNT7A基因甲基化在NSCLC患者中检出率较高，可作为NSCLC有效的诊断依据
%K WNT7A
%K 甲基化
%K 甲基化特异性聚合酶链反应
%K 病理类型
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%U http://www.zlfzyj.com/CN/abstract/abstract9528.shtml