CARMA3调控NF-κB信号通路激活的研究进展
Progress on regulation of NF κB signaling pathway by CARMA3

含半胱天冬酶募集结构域的膜相关鸟苷酸激酶蛋白3（caspase recruitment domain and membrane associated guanylate kinase like domain protein 3，CARMA3）属于CARMA家族，是一个新型的骨架蛋白。CARMA3通过调控NF κB信号通路的激活，影响细胞的周期进程、增殖和信号转导，从而影响癌症的发生和细胞应答。论文介绍了NF κB信号通路的激活过程、G蛋白偶联受体（G protein coupled receptors，GPCRs)的配体、DNA损伤和感染可激活CARMA3介导的NF κB信号通路、血管内皮生长因子（vascular endothelial growth factor，VEGF）的活性水平受CARMA3介导的NF κB信号通路的影响、A20负调控CARMA3介导的NF κB信号通路，以及CARMA3与癌症发生的关联，旨在为基于NF κB信号通路的细胞周期进程、增殖和细胞应答方面的研究提供参考。
CARMA3 (caspase recruitment domain and membrane associated guanylate kinase like domain protein 3) belongs to CARMA family and is a novel scaffold protein.By regulating the activation of NF-κB signaling pathway,CARMA3 controls cell cycle,proliferation and signal transduction,and consequently influences progression of cancers and cellular responses.Here,we comprehensively reviewed NF-κB signaling pathway activation process,including CARMA3 mediated NF-κB activation triggered by ligands of GPCRs (G protein coupled receptors),DNA damage or infection,influence of CARMA3 mediated NF-κB activation on VEGF (vascular endothelial growth factor) activity,negative regulation of A20 on CARMA3 mediated NF-κB activation,and the link between CARMA3 and cancers,aiming to provide reference for the study of cell cycle progression,proliferation and cellular responses based on NF κB signaling pathway