%0 Journal Article
%T CARMA3调控NF-κB信号通路激活的研究进展<br>Progress on regulation of NF κB signaling pathway by CARMA3
%A 周洋
%A 郑文燕
%A 胡帝宇
%A 童智子
%A 蒋松宏
%A 王怡丹
%J 华中农业大学学报
%D 2019
%X 含半胱天冬酶募集结构域的膜相关鸟苷酸激酶蛋白3（caspase recruitment domain and membrane associated guanylate kinase like domain protein 3，CARMA3）属于CARMA家族，是一个新型的骨架蛋白。CARMA3通过调控NF κB信号通路的激活，影响细胞的周期进程、增殖和信号转导，从而影响癌症的发生和细胞应答。论文介绍了NF κB信号通路的激活过程、G蛋白偶联受体（G protein coupled receptors，GPCRs)的配体、DNA损伤和感染可激活CARMA3介导的NF κB信号通路、血管内皮生长因子（vascular endothelial growth factor，VEGF）的活性水平受CARMA3介导的NF κB信号通路的影响、A20负调控CARMA3介导的NF κB信号通路，以及CARMA3与癌症发生的关联，旨在为基于NF κB信号通路的细胞周期进程、增殖和细胞应答方面的研究提供参考。<br>CARMA3 (caspase recruitment domain and membrane associated guanylate kinase like domain protein 3) belongs to CARMA family and is a novel scaffold protein.By regulating the activation of NF-κB signaling pathway,CARMA3 controls cell cycle,proliferation and signal transduction,and consequently influences progression of cancers and cellular responses.Here,we comprehensively reviewed NF-κB signaling pathway activation process,including CARMA3 mediated NF-κB activation triggered by ligands of GPCRs (G protein coupled receptors),DNA damage or infection,influence of CARMA3 mediated NF-κB activation on VEGF (vascular endothelial growth factor) activity,negative regulation of A20 on CARMA3 mediated NF-κB activation,and the link between CARMA3 and cancers,aiming to provide reference for the study of cell cycle progression,proliferation and cellular responses based on NF κB signaling pathway
%K 含半胱天冬酶募集结构域的膜相关鸟苷酸激酶蛋白3 （CARMA3） NF κB G蛋白偶联受体（GPCRs） 血管内皮生长因子（VEGF）<br>CARMA3
%U http://hnxbl.cnjournals.net/hznydxzr/ch/reader/view_abstract.aspx?file_no=20190420&flag=1