Serum Aspartic Acid ？as a Marker of Epilepsy | AlGawwam | Global Journal of Health Science | CCSE

OBJECTIVE: Determine the ？diagnostic validity of serum aspartic acid as a predictor of epilepsy. STUDY DESIGN & METHODOLOGY: This study enrolled 80 epileptic patients and 80 healthy people, and we measure serum level of ？aspartic acid by using high liquid performance chromatography. RESULTS: Mean serum aspartic acid ？was significantly higher in patients (26.2 ± 10.1) mg\dl while in control was (2.8 ± 1.36) mg\dl, ？the result showed that aspartic acid is an excellent predictor area under the curve [AUC] (95%CI) = ？？0.988 (0.97 – 1.0) with 96.3% sensitivity and 97.5% specificity for epileptic patients. Also, the ？result shows generalized seizure has significantly higher mean serum aspartic acid compared to ？partial type and GTC show significantly higher mean serum aspartic acid compared to ？myoclonus. CONCLUSION: Aspartic acid serum level markedly elevated in epileptic patients ？groups in comparison to the healthy group, also shows a marked difference between generalized ？and partial epilepsy and show different levels between subtypes of epilepsy.