Effect of nifedipine and glibenclamide addition in a model of high fat diet- induced hypertension and hyperlipidemia in rabbits receiving donepezil.

Geriatric individuals suffering from Alzheimer’s disease are frequently co-treated for hypertension and/or diabetes. In the current research, we have explored the addition of nifedipine (1 mg/ kg), glibenclamide (0.45 mg/kg) to donepezil (0.75 mg/kg) in a rabbit model of high fat diet- induced hypertension and hyperlipidemia. Nifedipine was shown to improve hypertension, lipid profile as well as the nitro-oxidative pathway when combined with donepezil. Glibenclamide has shown an improvement regarding hypertension and nitro-oxidative pathway when compared to the high fat diet receiving group. Keywords: Donepezil; Nifedipine; Glibenclamide; Alzheimer’s disease; hypertension; hyperlipidemi