%0 Journal Article
%T Effect of nifedipine and glibenclamide addition in a model of high fat diet- induced hypertension and hyperlipidemia in rabbits receiving donepezil.
%A MahaYehia Kamel
%A Mina Thabet Kelleni
%A SalwaAbdeltawab Ibrahim
%J Journal of Environmental Science and Toxicology | Journal of Toxicology | International Journals
%D 2017
%X Geriatric individuals suffering from Alzheimer¡¯s disease are frequently co-treated for hypertension and/or diabetes. In the current research, we have explored the addition of nifedipine (1 mg/ kg), glibenclamide (0.45 mg/kg) to donepezil (0.75 mg/kg) in a rabbit model of high fat diet- induced hypertension and hyperlipidemia. Nifedipine was shown to improve hypertension, lipid profile as well as the nitro-oxidative pathway when combined with donepezil. Glibenclamide has shown an improvement regarding hypertension and nitro-oxidative pathway when compared to the high fat diet receiving group. Keywords: Donepezil; Nifedipine; Glibenclamide; Alzheimer¡¯s disease; hypertension; hyperlipidemi
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