Toxicity and pharmacokinetic profile of SGM-101, a fluorescent anti-CEA chimeric antibody for fluorescence imaging of tumors in patients

DOI: 10.1016/j.toxrep.2019.04.011

Keywords: FGS, fluorescence guided surgery, NIR, near infra-red, ICG, indocyanine green, CEA, carcinoembryonic antigen, mAb, monoclonal antibody, GLP, Good Laboratory Practices, PK, pharmacokinetics, AUC, Area Under the Curve, MTD, maximum tolerated dose, MRT, Mean Residence Time, NOAEL, no observable adverse effect level (NOAEL), TMDD, target-mediated drug disposition Carcinoembryonic antigen, Cancer, Fluorescence guided surgery, Near-infrared fluorochrome, Toxicity, Pharmacokinetics

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