Differential impact of diabetes mellitus on antiplatelet effects of prasugrel and clopidogrel

Study design at loading dose. Forty patients who were scheduled for percutaneous coronary intervention (PCI) under treatment with aspirin were randomized at admission to treatment of either a 20-mg loading dose (LD) of prasugrel or a 300-mg LD of clopidogrel. Platelet function analyses were performed at five time points (baseline, and 0.5, 3, 6, and 20 h) after the LD. Active metabolite concentrations were measured at 0.5 and 3 h after the L