Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression

Groups defined by risk alleles are colored red, those by control alleles are turquoise and heterozygote groups are beige. a Mean BPND is grouped by rs6265 genotype (AA？=？3, AG？=？17, GG？=？26). b BPND is grouped by rs6295 genotype (CC？=？10, CG？=？19, GG？=？13). c Groups are defined by the absolute number of risk alleles G of rs6295 and A of rs6265, ranging from 0 to 4 (0, n？=？7; 1, n？=？11; 2, n？=？20; 3, n？=？7; 4, n？=？1). d BPND is grouped by genotypic group with control (n？=？38) and risk phenotypes, the latter requiring at least 3 risk alleles (n？=？8). The difference in mean BPND did not reach statistical significance for any compariso