%0 Journal Article
%T Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression
%A Alexander Kautzky
%A Annette M. Hartmann
%A Cecile Philippe
%A Christoph Kraus
%A Dan Rujescu
%A Georg S. Kranz
%A Gregor Gryglewski
%A Gregory M. James
%A Markus Mitterhauser
%A Pia Baldinger-Melich
%A Rupert Lanzenberger
%A Siegfried Kasper
%A Thomas Vanicek
%A Wolfgang Wadsak
%J Archive of "Translational Psychiatry".
%D 2019
%R 10.1038/s41398-018-0308-2
%X Groups defined by risk alleles are colored red, those by control alleles are turquoise and heterozygote groups are beige. a Mean BPND is grouped by rs6265 genotype (AA£¿=£¿3, AG£¿=£¿17, GG£¿=£¿26). b BPND is grouped by rs6295 genotype (CC£¿=£¿10, CG£¿=£¿19, GG£¿=£¿13). c Groups are defined by the absolute number of risk alleles G of rs6295 and A of rs6265, ranging from 0 to 4 (0, n£¿=£¿7; 1, n£¿=£¿11; 2, n£¿=£¿20; 3, n£¿=£¿7; 4, n£¿=£¿1). d BPND is grouped by genotypic group with control (n£¿=£¿38) and risk phenotypes, the latter requiring at least 3 risk alleles (n£¿=£¿8). The difference in mean BPND did not reach statistical significance for any compariso
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341100/