Letter to the Editor regarding the article ‘Left atrial volume index in patients with heart failure and severely impaired left ventricular systolic function: the role of established echocardiographic parameters, circulating cystatin C and galectin-3’ by Zivlas et al. (2017)

We have read the article by Zivlas and colleagues in which the authors suggest a putative pathogenic role for cystatin C (Cys-C) and galectin-3 (Gal-3) in heart failure (HF) progression and cardiorenal syndrome. They even speculate on the possibility of targeting both molecules as a new therapeutic approach to address both processes.