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ISSN: 2333-9721
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-  2016 

Transcription of Leishmania major U2 small nuclear RNA gene is directed by extragenic sequences located within a tRNA-like and a tRNA-Ala gene

DOI: 10.1186/s13071-016-1682-3

Keywords: Leishmania, U2 snRNA, Promoter region, tRNA-like, Pseudouridine

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Abstract:

Leishmania and other trypanosomatid parasites possess atypical mechanisms of gene expression, including the maturation of mRNAs by trans-splicing and the involvement of RNA Polymerase III in transcription of all snRNA molecules. Since snRNAs are essential for trans-splicing, we are interested in the study of the sequences that direct their expression. Here we report the characterization of L. major U2 snRNA promoter region

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