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-  2017 

Biological Effects of Hesperetin on Interleukin-6/Phosphorylated Signal Transducer and Activator of Transcription 3 Pathway Signaling in Prostate Cancer PC3 Cells

DOI: 10.4103/0974-8490.204655

Keywords: Hesperetin, interleukin-6, pAKT, phosphorylated extracellular signal-regulated kinases 1/2, phosphorylated signal transducer and activator of transcription 3, prostate cancer

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Abstract:

Interleukin-6 (IL-6) is a multifunctional glycoprotein that regulates the growth of some tumors, including prostate carcinomas due to signal transducer and activator of transcription 3 (STAT3), extracellular signal-regulated kinases 1/2 (ERK1/2), and AKT signaling pathways. Hesperetin, as a flavanone, has several biological properties such as antitumor and anti-inflammatory

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