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-  2016 

MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

DOI: 10.1080/2162402X.2016.1159370

Keywords: Immunotherapy, MHC multimers, neoantigens, T-cells, TCR, tumor immunology

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Abstract:

Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy

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