Disruption of evasive immune cell microenvironment in tumors reflects immunity induced by radiation therapy

Radiation administered to murine colon tumors induced durable remissions that were dependent on CD4+ and CD8+ T cell immunity, and antigen cross priming CD8+ dendritic cells (DCs). Remissions were associated with marked reductions in the infiltration of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and Treg cells, and a marked increase in CD8+ T cells