INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) is commonly used for
refractory cardiac or respiratory failure. There are reported cases of
successful use of ECMO in patients with septic shock; however, there is a lack
of evidence to prove its overall efficacy. Thus, we conducted this study to
analyze the relationship between sepsis and ECMO in our own patients.METHODS: 305 patients who were placed on ECMO between 2010 and 2020 were identified
within an IRB-approved database. Their clinical outcomes were analyzed with a specific focus on patients who were
septic before or during ECMO, defined as a positive blood culture. Group S was
composed of patients with a positive blood culture before or during ECMO, while
Group N was composed of all patients without a positive blood culture before or
during ECMO. The primary outcome compared between groups was ECMO survival rate. RESULTS: Among the
305 patients on ECMO, 58 (19%) were in Group S and 247 (81%) were in Group N.
ECMO survival rates were 45% in Group S and 62% in Group N (p = 0.017).CONCLUSION: Of our 305 patients, patients who were septic upon
ECMO placement or those who
developed sepsis during ECMO had worse ECMO survival rates than non-septic
patients. Ultimately, patients who are septic or have a high probability of
becoming septic may not be indicated for ECMO placement, and cautious
administration of ECMO to
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