A geroscience mouse model for Alzheimer’s disease

Geroscience is a multidisciplinary field that examines the relationship between biological aging and age-related diseases [1]. Seven processes discussed by the trans-NIH Geroscience Interest Group Summit that contribute to biological aging included macromolecular damage, epigenetic changes, inflammation, adaptation to stress, impairments to proteostasis, stem cell regeneration, and metabolism [2]. These processes are highly integrated with one another such that targeting them as a group may be an effective approach to developing therapies to prevent or delay age-related disease