%0 Journal Article
%T A geroscience mouse model for Alzheimer¡¯s disease
%A Dirk Keene
%A Martin Darvas
%A Warren Ladiges
%J Archive of "Pathobiology of Aging & Age Related Diseases".
%D 2019
%R 10.1080/20010001.2019.1616994
%X Geroscience is a multidisciplinary field that examines the relationship between biological aging and age-related diseases [1]. Seven processes discussed by the trans-NIH Geroscience Interest Group Summit that contribute to biological aging included macromolecular damage, epigenetic changes, inflammation, adaptation to stress, impairments to proteostasis, stem cell regeneration, and metabolism [2]. These processes are highly integrated with one another such that targeting them as a group may be an effective approach to developing therapies to prevent or delay age-related disease
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522959/