Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors

Ablation of VGlut2 mRNA and protein following CAV-Cre injection into the dorsal striatum in CAV2Cre-Slc17a6lox/lox mice. a Schematic representation showing the position of loxP sites inserted into the Slc17a6 locus of Slc17a6lox/lox mice. b Illustration of needle placement for CAV2-Cre injections into CAV2Cre-Slc17a6+/+ controls and CAV2Cre-Slc17a6lox/lox mice. c Expression of VGLUT2 protein in the dorsal striatum of CAV2Cre-Slc17a6+/+ controls (n？=？6) and CAV2Cre-Slc17a6lox/lox (n？=？8) mice as measured by LUMINEX quantification. d Expression of Slc17a6 mRNA in the CL thalamic nucleus of CAV2Cre-Slc17a6+/+ controls (n？=？10) and CAV2Cre-Slc17a6lox/lox (n？=？12) mice. e Expression of Slc17a6 mRNA in the CM/PF thalamic nuclei of CAV2Cre-Slc17a6+/+ controls (n？=？10) and CAV2Cre-Slc17a6lox/lox (n？=？12) mice. Data in all figures are shown as mean？±？standard error of mean (SEM). Statistical significance of pairwise comparison of means from CAV2Cre-Slc17a6+/+ controls and CAV2Cre-Slc17a6lox/lox mice are shown. *p？<？0.0