%0 Journal Article
%T Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors
%A Alec W. Gibson
%A Charles W. Henschen
%A Erica J. Melief
%A John F. Neumaier
%A Jonathan W. McKinley
%A Jonathan Y. Lam
%A Martin Darvas
%A Nicole M. Whiteley
%A Nigel S. Bamford
%A Richard D. Palmiter
%J Archive of "NPJ Parkinson's Disease".
%D 2018
%R 10.1038/s41531-018-0060-6
%X Ablation of VGlut2 mRNA and protein following CAV-Cre injection into the dorsal striatum in CAV2Cre-Slc17a6lox/lox mice. a Schematic representation showing the position of loxP sites inserted into the Slc17a6 locus of Slc17a6lox/lox mice. b Illustration of needle placement for CAV2-Cre injections into CAV2Cre-Slc17a6+/+ controls and CAV2Cre-Slc17a6lox/lox mice. c Expression of VGLUT2 protein in the dorsal striatum of CAV2Cre-Slc17a6+/+ controls (n£¿=£¿6) and CAV2Cre-Slc17a6lox/lox (n£¿=£¿8) mice as measured by LUMINEX quantification. d Expression of Slc17a6 mRNA in the CL thalamic nucleus of CAV2Cre-Slc17a6+/+ controls (n£¿=£¿10) and CAV2Cre-Slc17a6lox/lox (n£¿=£¿12) mice. e Expression of Slc17a6 mRNA in the CM/PF thalamic nuclei of CAV2Cre-Slc17a6+/+ controls (n£¿=£¿10) and CAV2Cre-Slc17a6lox/lox (n£¿=£¿12) mice. Data in all figures are shown as mean£¿¡À£¿standard error of mean (SEM). Statistical significance of pairwise comparison of means from CAV2Cre-Slc17a6+/+ controls and CAV2Cre-Slc17a6lox/lox mice are shown. *p£¿<£¿0.0
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072777/