Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson’s disease

Representative images of pre and post synaptic immunoreactivity. Synaptic terminals of dopaminergic SN neurons within the striatum were analysed. Pre-synaptic terminals were visualised using reactivity for the dopamine transporter, DAT (green, 488？nm). Images were taken of pre-synaptic terminals surrounding a post synaptic neuron, post synaptic regions were visualised using reactivity for the dopamine D2 receptor (red, 546？nm). Pre and post synaptic volume was measured in tissue from patients with PD (a), DLB (b), AD (c) and in age matched controls (d). Scale bar represents 10？μ