%0 Journal Article
%T Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson¡¯s disease
%A Amy K. Reeve
%A Christopher M. Morris
%A Chun Chen
%A Emma Bennison
%A Eve M. Cosgrave
%A John P. Grady
%A Philippa D. Hepplewhite
%J Archive of "NPJ Parkinson's Disease".
%D 2018
%R 10.1038/s41531-018-0044-6
%X Representative images of pre and post synaptic immunoreactivity. Synaptic terminals of dopaminergic SN neurons within the striatum were analysed. Pre-synaptic terminals were visualised using reactivity for the dopamine transporter, DAT (green, 488£¿nm). Images were taken of pre-synaptic terminals surrounding a post synaptic neuron, post synaptic regions were visualised using reactivity for the dopamine D2 receptor (red, 546£¿nm). Pre and post synaptic volume was measured in tissue from patients with PD (a), DLB (b), AD (c) and in age matched controls (d). Scale bar represents 10£¿¦Ì
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979968/