Extracellular vesicle-mediated EBAG9 transfer from cancer cells to tumor microenvironment promotes immune escape and tumor progression

a Representative genitourinary organs. Ebag9KO mice were crossed with TRAMP mice to generate Ebag9KO;TRAMP(+) and control Ebag9WT;TRAMP(+) mice. Genitourinary organs were dissected from these male mice at 1 year old. Scale bar, 1？cm. b Prostate tumor development was repressed in Ebag9KO;TRAMP(+) mice. Genitourinary organ weight was measured at 1 year old. c Upregulation of Cd8 mRNA in prostate tumors generated in Ebag9KO;TRAMP(+) mice. qRT-PCR analysis of Cd8 mRNA was performed using RNAs from prostate tumors. The data are shown as mean？±？SD (Ebag9KO;TRAMP(+), n？=？10; Ebag9WT;TRAMP(+), n？=？17). *P？<？0.05 (two-sided Student’s t-test