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-  2017 

CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy

DOI: 10.1080/2162402X.2016.1273302

Keywords: Adoptive T-cell therapy, breast cancer, immunosuppression, lung cancer, mesothelioma, PD-1 blockade, tumor microenvironment

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Abstract:

PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells with checkpoint blockade is a promising treatment approach for solid tumors

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