%0 Journal Article
%T CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy
%A Aurore Morello
%A Nan Chen
%A Prasad S. Adusumilli
%A Zachary Tano
%J Archive of "Oncoimmunology".
%D 2017
%R 10.1080/2162402X.2016.1273302
%X PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells with checkpoint blockade is a promising treatment approach for solid tumors
%K Adoptive T-cell therapy
%K breast cancer
%K immunosuppression
%K lung cancer
%K mesothelioma
%K PD-1 blockade
%K tumor microenvironment
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353939/