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-  2017 

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy

DOI: 10.1080/2162402X.2016.1265721

Keywords: Cytokine, cytotoxic lymphocytes, immunotargeting, immunotherapy, Interleukin-2 (IL-2), natural killer cell (NK), NKG2D

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Abstract:

The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side effects such as activation of regulatory T cells and vascular endothelium

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