%0 Journal Article
%T Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy
%A Alexander Sasha Krupnick
%A Dan Watkins
%A Daved H. Fremont
%A Eric Lazear
%A John Westwick
%A Reza Ghasemi
%A Sarah M. Hein
%J Archive of "Oncoimmunology".
%D 2017
%R 10.1080/2162402X.2016.1265721
%X The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side effects such as activation of regulatory T cells and vascular endothelium
%K Cytokine
%K cytotoxic lymphocytes
%K immunotargeting
%K immunotherapy
%K Interleukin-2 (IL-2)
%K natural killer cell (NK)
%K NKG2D
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353927/