Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors

a Percentage of 15-week-old RT2 mice with liver metastasis, by genetic background. All mice were males, and 18 mice from each lineage were analyzed. Statistical significance was determined using Fisher’s exact test. B6 mice have the C57Bl/6 genetic background, and AB6F1 mice are hybrids resulting from mating female A/J mice to male C57Bl/6 mice. b Volume of primary pancreatic tumors according to the genetic background. All mice were 17-week-old males; 24 RT2 B6 mice and 138 RT2 AB6F1 mice were analyzed. Statistical significance was determined using Mann–Whitney test. c Kaplan–Meier survival curves for RT2 mice between 6 and 16 weeks of age according to the genetic background. d Eight hours after removal of food, serum glucose was measured in RT2 mice of different genetic backgrounds. All mice were males and 12–13 weeks old. Fifteen RT2 AB6F1 and 12 RT2 B6 were analyzed. Statistical significance was determined using two-tailed t-test. e RT2 mice or wildtype littermates were held without food for 8？h, then serum insulin was measured and compared to littermates (B6 or AB6F1) lacking the SV40 T-antigen transgene. Mice were males and 13 weeks old. Nine and 11 RT2 B6 and RT2 AB6F1 mice were measured, respectively. Statistical significance was determined using two-tailed t-tes