%0 Journal Article
%T Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors
%A Chris R. Harris
%A Evan Vosburgh
%A Laura H. Tang
%A Richard Clausen
%A Shinta Kobayashi
%A Tanupriya Contractor
%A Yi-Chieh Nancy Du
%J Archive of "Oncogenesis".
%D 2019
%R 10.1038/s41389-019-0127-1
%X a Percentage of 15-week-old RT2 mice with liver metastasis, by genetic background. All mice were males, and 18 mice from each lineage were analyzed. Statistical significance was determined using Fisher¡¯s exact test. B6 mice have the C57Bl/6 genetic background, and AB6F1 mice are hybrids resulting from mating female A/J mice to male C57Bl/6 mice. b Volume of primary pancreatic tumors according to the genetic background. All mice were 17-week-old males; 24 RT2 B6 mice and 138 RT2 AB6F1 mice were analyzed. Statistical significance was determined using Mann¨CWhitney test. c Kaplan¨CMeier survival curves for RT2 mice between 6 and 16 weeks of age according to the genetic background. d Eight hours after removal of food, serum glucose was measured in RT2 mice of different genetic backgrounds. All mice were males and 12¨C13 weeks old. Fifteen RT2 AB6F1 and 12 RT2 B6 were analyzed. Statistical significance was determined using two-tailed t-test. e RT2 mice or wildtype littermates were held without food for 8£¿h, then serum insulin was measured and compared to littermates (B6 or AB6F1) lacking the SV40 T-antigen transgene. Mice were males and 13 weeks old. Nine and 11 RT2 B6 and RT2 AB6F1 mice were measured, respectively. Statistical significance was determined using two-tailed t-tes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386750/