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-  2019 

Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity

DOI: 10.1002/osp4.326

Keywords: Injection depot, insulin pharmacokinetics, obesity, subcutaneous administration

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Abstract:

Obesity is associated with delayed insulin absorption upon subcutaneous (s.c.) dosing in humans. The aim of this study was to investigate whether alterations in depot structure and kinetics of the s.c. injection depot contribute to this delay

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