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-  2018 

Maternal overnutrition by hypercaloric diets programs hypothalamic mitochondrial fusion and metabolic dysfunction in rat male offspring

DOI: 10.1186/s12986-018-0279-6

Keywords: Maternal overnutrition, Diet induced obesity (DIO), Hypothalamus, Mitochondria, Mitochondria dynamics, Fusion, Fission

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Abstract:

Effect of nutritional programming on dams and male offspring weight. a) Animal model. We fed female Wistar rats for 9 weeks according to the schedule to promote maternal programming or we fed offspring with hypercaloric diet exposure after weaning. b) Maternal body weight was followed for 6 weeks (pre-mating, mating and gestation) (Control n?=?7, HFD n?=?7, CAF n?=?6 and HSD n?=?4). c) Birth weight of offspring at day 0. d) Body weight after weaning for Control versus HFD-C, CAF-C, HSD-C for maternal programming groups, where HFD, CAF and HSD are maternal diet and C is control chow diet of offspring. e) Body weight after weaning for Control versus offspring fed with HFD, CAF and HSD after weaning (HFD-HFD, CAF-CAF, HSD-HSD groups). Data are means ± SD. *p?<?0.05, **p?<?0.01 and ***p?<?0.00

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