FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3β-related pathways

a The hazard risk (HR) distribution of 56 genes with high expression and association with poor prognosis based on TCGA raw data from cBioPortal. The filtering criteria are p？<？0.05 and HR？>？0. b Venn diagram showing that FIBP, HSFY1, and PPM1K are simultaneously present in both the set of genes with a high HR and the set of genes downregulated by curcumin. c Expression of FIBP was higher in CRC specimens with chemoresistance (CR) than in chemosensitive tissue. n？=？10 for the CRC group, and n？=？6 for the CRC with CR group. d Representative immunochemistry staining results in tumors with/without chemoresistance (magnification, ×200). e Kaplan–Meier survival curves according to FIBP levels. *p？<？0.05 CRC vs. CRC with C