Identification of strong intron enhancer in the heparanase gene: effect of functional rs4693608 variant on HPSE enhancer activity in hematological and solid malignancies

The size of analyzed enhancer region is 440？bp. It includes four polymorphic SNPs: rs4693083, rs4693608, rs4693084, and rs4693609. The map represents exact location of the SNPs and nucleotide substitution. The distance between rs4693083 and rs4693608 is 40？bp, whereas the interval between rs4693608 and rs4693084 is 17？bp. Additional rs4693609 SNP is located 199？bp upstream of rs469308