Investigating the accuracy, risk impact, and cost-effectiveness of component-resolved diagnostic test for food allergy: a systematic review protocol

Food allergy—particularly immunoglobulin E (IgE)-mediated food allergy—is now a global public health problem. It results in considerable morbidity, healthcare utilisation, and impairment in quality of life.1–6 Food allergy reactions range in severity from relatively mild features to life-threatening anaphylaxis.2, 3 Estimates of the prevalence of food allergy vary, but overall lifetime prevalence has been estimated as affecting up to 7% of children and 6% of adults.4,