IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight

Effect of body weight on IL-6 production by cultured peripheral blood mononuclear cells. This figure is from a publication on the effect of long-term exercise on peripheral blood mononuclear cell (PBMC) production of osteoclastogenic and anti-osteoclastogenic cytokines.4 a Spontaneous production of IL-6 by cultured PBMC (N？=？41 subjects). b IL-6 production in PBMC cultures containing the T-cell mitogen phytohemagglutinin (PHA) (N？=？41 subjects). c IL-6 production by PBMC of women in PHA？+？cultures (N？=？23 subjects). d IL-6 production by PBMC of men in PHA？+？cultures (N？=？18 subjects). (Linear regression analyses with 95% confidence intervals