Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides

Effect of OligoG on inhibition of mucoid biofilm formation: Imaging and quantification of P. aeruginosa (NH57388A) biofilms grown for 24？h at 37？°C in MH broth？±？OligoG (0.5%, 2% & 6%). a SEM imaging of biofilms (Scale bar, 10？μm). b CLSM 3D imaging (aerial view) of LIVE/DEAD？ staining of biofilms (Scale bar, 20？μm). c COMSTAT image analysis of the corresponding biofilm CLSM z-stack images. *P？<？0.05 significance was determined by comparison to the untreated control. Error bars represent the standard deviation of the data set (n？=？3