Ranking network mechanisms by how they fit diverse experiments and deciding on E. coli's ammonium transport and assimilation network

Schematic diagram of the E. coli ammonium transport and assimilation network. For simplicity, CADLIVE notation14,24,25 was used. Blue lines: activation, red lines: inhibition, green lines: catalytic action. The thick grey line indicates cytoplasmic membrane. The following abbreviations were used. GS: glutamine synthetase, GDH: glutamate dehydrogenase, GOGAT: glutamate synthase, ATase: adenylyltransferase/adenylyl-removing enzyme, UTase: uridylyltransferase/uridylyl-removing enzyme, GlnB and GlnK: nitrogen regulatory proteins, AmtB: ammonium transporter, OG: 2-oxoglutarate, GLU: glutamate, GLN: glutamin