MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9

a Expression levels of miR-215-5p are significantly decreased in CRC tissues compared with healthy adjacent tissues (P？<？0.0001; Czech cohort). b Expression levels of miR-215-5p are significantly decreased in CRC tissues compared with healthy adjacent tissues (P？<？0.0001; Spain cohort). c Expression of miR-215-5p significantly decreases with advanced clinical stage (P？<？0.0001; Czech cohort). d Expression of miR-215-5p significantly decreases with advanced clinical stage (P？=？0.0185; Spain cohort). e Low levels of miR-215-5p correlate with shorter OS of Czech CRC patients (P？=？0.0024). f Low levels of miR-215-5p correlate with shorter OS of Spain CRC patients (P？=？0.0111). OS overall surviva