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- 2016
Orphan devices: yesterday is history; tomorrow is mystery: towards a European orphan device directive?DOI: 10.1186/s13023-016-0393-3 Keywords: History of medicine, Rare diseases, Orphan drugs, Custom-made medical devices, Humanitarian-use devices Abstract: Regulatory and economic frameworks stimulated the research and development of orphan drugs, but very little has been done for devices necessary for the in-vivo diagnosis, prevention and treatment of life-threatening conditions with a low prevalence/incidence
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