%0 Journal Article
%T Orphan devices: yesterday is history; tomorrow is mystery: towards a European orphan device directive?
%A Marc M Dooms
%J Archive of "Orphanet Journal of Rare Diseases".
%D 2016
%R 10.1186/s13023-016-0393-3
%X Regulatory and economic frameworks stimulated the research and development of orphan drugs, but very little has been done for devices necessary for the in-vivo diagnosis, prevention and treatment of life-threatening conditions with a low prevalence/incidence
%K History of medicine
%K Rare diseases
%K Orphan drugs
%K Custom-made medical devices
%K Humanitarian-use devices
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778287/