Signal integration and information transfer in an allosterically regulated network

Network interactions within CORM. a The Multi-input Multi-output motif in a biological context. b The COX-2 Reaction Model (CORM) represents the network of interactions in the COX-2 system. The diagram depicts the possible biochemical states that the COX-2 enzyme (blue lozenges) can adopt through its allosteric (lower left circle) and catalytic (lower right circle) subunits, respectively. AA bound in either site is indicated with A and 2-AG with G within the circle. AA is turned over to produce prostaglandin (PG) and 2-AG is turned over to produce prostaglandin-glycerol (PG-G). Double-headed arrows indicate reversible reactions while single-headed arrows indicate irreversible reactions. Credible intervals for all fitted parameters are included in SI. c Dominant PG Production Paths in CORM. Colors correspond to path fluxes in Fig. Fig.2a.2a. d Dominant PG-G Production Paths in CORM. Colors correspond to path fluxes in Fig. Fig.2b2