%0 Journal Article
%T Signal integration and information transfer in an allosterically regulated network
%A Carlos F. Lopez
%A Carol A. Rouzer
%A Eric J. Deeds
%A Erin M. Shockley
%A Lawrence J. Marnett
%J Archive of "NPJ Systems Biology and Applications".
%D 2019
%R 10.1038/s41540-019-0100-9
%X Network interactions within CORM. a The Multi-input Multi-output motif in a biological context. b The COX-2 Reaction Model (CORM) represents the network of interactions in the COX-2 system. The diagram depicts the possible biochemical states that the COX-2 enzyme (blue lozenges) can adopt through its allosteric (lower left circle) and catalytic (lower right circle) subunits, respectively. AA bound in either site is indicated with A and 2-AG with G within the circle. AA is turned over to produce prostaglandin (PG) and 2-AG is turned over to produce prostaglandin-glycerol (PG-G). Double-headed arrows indicate reversible reactions while single-headed arrows indicate irreversible reactions. Credible intervals for all fitted parameters are included in SI. c Dominant PG Production Paths in CORM. Colors correspond to path fluxes in Fig. Fig.2a.2a. d Dominant PG-G Production Paths in CORM. Colors correspond to path fluxes in Fig. Fig.2b2
%K Systems analysis
%K Biochemical networks
%K Signal processing
%K Computer modelling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639376/