Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress in Pruritus

Antioxidants decreased histamine-dependent acute itch induced by compound 48/80 in mice. A, B Systemic administration of NAC (100–500 mg/kg, i.p.) dose-dependently decreased scratching behavior induced by compound 48/80. C, D Systemic administration of PBN (50–200 mg/kg, i.p.) dose-dependently attenuated compound 48/80-induced itch (**P < 0.01, ***P < 0.001 vs control, one-way ANOVA followed by Dunnett’s test; n = 5–6 mice/group)