%0 Journal Article
%T Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress in Pruritus
%A Feng-Ming Zhou
%A Li-Hua Chen
%A Ruo-Xiao Cheng
%A Shuai Wang
%A Teng-Teng Liu
%A Tong Liu
%A Xue-Long Wang
%A Ya Huang
%A Yan Zhou
%A Yong-Jing Gao
%J Archive of "Neuroscience Bulletin".
%D 2017
%R 10.1007/s12264-016-0076-z
%X Antioxidants decreased histamine-dependent acute itch induced by compound 48/80 in mice. A, B Systemic administration of NAC (100¨C500 mg/kg, i.p.) dose-dependently decreased scratching behavior induced by compound 48/80. C, D Systemic administration of PBN (50¨C200 mg/kg, i.p.) dose-dependently attenuated compound 48/80-induced itch (**P < 0.01, ***P < 0.001 vs control, one-way ANOVA followed by DunnettĄ¯s test; n = 5¨C6 mice/group)
%K Oxidative stress
%K Antioxidants
%K Itch
%K TRPA1
%K Extracellular signal-regulated kinase
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567556/