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- 2017
Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 ReceptorsDOI: 10.1007/s12264-017-0127-0 Keywords: Orexin, OX1 receptor, OX2 receptor, Globus pallidus internus, Basal ganglia Abstract: Orexin-A excites two types of GPi neurons. A Diagram of rat brain in sagittal view showing the location of the GPi between 1.92 and 2.76 mm from bregma. B A coronal brain slice containing the GPi. C, D Electrophysiological identification of Types I and II neurons in the GPi and the effect of orexin-A. The diameters of both types were >20 μm (arrowheads). Type I neurons showed a voltage sag during injection of a negative current step, whereas Type II neurons (n = 8, 10.5%) showed little or none. GPi, internal globus pallidus; ic, internal capsule
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