Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway

a HE and Oil Red O staining of liver sections after As2O3 administration and pretreatment with Tau. Yellow arrows indicate steatosis. b–d mRNA levels of lipid-associated genes in liver tissues after exposure to As2O3 and pretreatment with Tau, performed by qPCR. c F4/80 immunofluorescence staining of liver sections following As2O3 and Tau treatment. Yellow arrows indicate positive staining. e The content of triglyceride in mice livers. f The expression of liver inflammation-related proteins following exposure to As2O3 and Tau. The protein fraction was analyzed by western blot. g NAS in mouse livers. Values are mean？±？SD, and n？=？6. *P？<？0.05 compared with the control group, #P？<？0.05 compared with the 4？mg/L group; Scale bar？=？100？μ